P26 MIR-101-3P CONTROLS TRIB1 EXPRESSION IN HUMAN MACROPHAGES: A POTENTIAL TARGET IN ATHEROSCLEROTIC PLAQUES
نویسندگان
چکیده
منابع مشابه
Expression of miR-485-3p and its Target FOXD3 in Chronic Lymphocytic Leukemia
Background and Aims: Previous investigations have revealed that microRNAs (miRNAs) can function as oncogenes or tumor suppressors in chronic lymphocytic leukemia (CLL) and that the expression of miRNAs, such as miR-485-3p changes in several illnesses. This study was designed to determine the expression level of miR-485-3p and its target FOXD3 in CLL patients and controls to identify if this miR...
متن کاملEffect of Helicobacter pylori DNA in human atherosclerotic plaques
Introduction: A number of studies have demonstrated that infectious mico organisms like helicobacter pylori may play a role in the process of atherosclerosis. We, here, aimed to investigate the effect of Helicobacter pylori DNA in atherosclerotic plaques in patients with coronary artery disease. Methods: In a cross-sectional study, 85 patients undergoing coronary artery bypass graft (CAB...
متن کاملNeutrophil elastase in human atherosclerotic plaques: production by macrophages.
BACKGROUND Catabolism of the extracellular matrix (ECM) contributes to vascular remodeling in health and disease. Although metalloenzymes and cysteinyl proteinases have garnered much attention in this regard, the role of serine-dependent proteinases in vascular ECM degradation during atherogenesis remains unknown. We recently discovered the presence of the metalloproteinase MMP-8, traditionally...
متن کاملExpression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.
OBJECTIVE Lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein, has been demonstrated to induce multiple functional alterations of vasculature that are potentially involved in atherosclerosis. Recently, an orphan G-protein-coupled receptor, G2A, has been identified as a high-affinity receptor for LPC. Although it has been demonstrated that G2A is exp...
متن کاملSelective Depletion of Macrophages in Atherosclerotic Plaques
In recent years, various animal models showed that macrophages are ubiquitous in all stages of atherosclerosis, and that they have a tremendous impact on lesion progression.1,2 The osteopetrotic (op) mouse, for example, has a spontaneously derived mutation in the gene encoding macrophage colony-stimulating factor, resulting in severely reduced blood monocytes and peritoneal macrophages.3 In an ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2018
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvy216.029